The mouthpiece can be removed and cleaned with soap and water, rubbing alcohol or hydrogen peroxide. Any debris blocking the air holes can be pushed out from the barbed fitting end with a small wire or compressed air. Soaking can help.
In multi-user settings, individual mouthpieces are recommended.
Once clean, any calcium deposits, which can show up as white specks, can be removed by soaking in a mild acid, like vinegar or lemon juice.
The PLA material currently being used is compatible with ETO and can be autoclaved after cleaning.