The Console Tuner Titan Two and the CronusMax Zen direct connection methods require the use of a PS4 Specialty controller for "Authentication", or a special dongal for the CM Zen. The DualSense controller that comes with the PS5 will NOT work for authenticating 3rd party crossover controllers like the Quadstick.
The Titan Two instructions are currently incomplete on their website. The Output Protocol must be set to Automatic (not PS5).
See the Console TunerForum for the latest information on support for the PS5.
The Quadstick is set up just like for the PS4, with both the "Boot in PS4 USB mode" and "Titan Two PS4 flag" enabled in the Misc tab of QMP. The Quadstick should be running a recent firmware build, like 2328 or later.
Specialty controllers that can be used for Authentication of Cronus Zen or Titan Two: